Human Gene KBTBD7 (uc001uxw.1)
Description: hom*o sapiens kelch repeat and BTB (POZ) domain containing 7 (KBTBD7), mRNA. RefSeq Summary (NM_032138): The protein encoded by this gene is a transcriptional activator, having been shown to increase the transcription of activator protein-1 and serum response element. The encoded protein can also form a complex with KBTBD6 and CUL3, which regulates the ubiquitylation and degradation of TIAM1, which is a regulator of RAC1. [provided by RefSeq, Jul 2016]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Transcript (Including UTRs) Position:hg19 chr13:41,765,711-41,768,702Size:2,992Total Exon Count:1Strand:- Coding Region Position:hg19 chr13:41,766,339-41,768,393Size:2,055Coding Exon Count:1
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Sequence and Links to Tools and Databases
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Comments and Description Text from UniProtKB
ID: KBTB7_HUMAN DESCRIPTION: RecName: Full=Kelch repeat and BTB domain-containing protein 7; INTERACTION: O95166:GABARAP; NbExp=2; IntAct=EBI-473695, EBI-712001; Q9H0R8:GABARAPL1; NbExp=3; IntAct=EBI-473695, EBI-746969; P60520:GABARAPL2; NbExp=2; IntAct=EBI-473695, EBI-720116; Q9GZQ8:MAP1LC3B; NbExp=3; IntAct=EBI-473695, EBI-373144; Q9BXW4:MAP1LC3C; NbExp=2; IntAct=EBI-473695, EBI-2603996; SIMILARITY: Contains 1 BTB (POZ) domain. SIMILARITY: Contains 5 Kelch repeats. |
Primer design for this transcript
Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA. Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence. To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3 |
Comparative Toxicogenomics Database (CTD)
The following chemicals interact with this gene
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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Highest median expression: 5.33 RPKM in Brain - Cerebellar Hemisphere Total median expression: 100.59 RPKM View in GTEx track of Genome BrowserView at GTEx portalView GTEx Body Map |
mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have. |
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR011705 - BACK IPR000210 - BTB/POZ-like IPR011333 - BTB/POZ_fold IPR013069 - BTB_POZ IPR017096 - Kelch-like_gigaxonin IPR015915 - Kelch-typ_b-propeller IPR006652 - Kelch_1 Pfam Domains: SCOP Domains: ModBase Predicted Comparative 3D Structure on Q8WVZ9
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene. |
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0003674 molecular_function GO:0005515 protein binding GO:0004842 ubiquitin-protein transferase activity Biological Process: Cellular Component: |
Descriptions from all associated GenBank mRNAs
LP895282 - Sequence 146 from Patent EP3253886. AL136782 - hom*o sapiens mRNA; cDNA DKFZp434E2318 (from clone DKFZp434E2318). AK091344 - hom*o sapiens cDNA FLJ34025 fis, clone FCBBF2003336, weakly similar to RING CANAL PROTEIN. AX746923 - Sequence 448 from Patent EP1308459. BC022033 - hom*o sapiens kelch repeat and BTB (POZ) domain containing 7, mRNA (cDNA clone MGC:26978 IMAGE:4825536), complete cds. FJ150424 - hom*o sapiens kelch repeat and BTB POZ-domain containing 7 (KBTBD7) mRNA, complete cds. JD541483 - Sequence 522507 from Patent EP1572962. AK299614 - hom*o sapiens cDNA FLJ51290 complete cds, highly similar to Kelch repeat and BTB domain-containing protein 7. JD288667 - Sequence 269691 from Patent EP1572962. JD504107 - Sequence 485131 from Patent EP1572962. CR533558 - hom*o sapiens full open reading frame cDNA clone RZPDo834H0521D for gene KBTBD7, kelch repeat and BTB (POZ) domain containing 7; complete cds, incl. stopcodon. AK315589 - hom*o sapiens cDNA, FLJ96667. KJ894932 - Synthetic construct hom*o sapiens clone ccsbBroadEn_04326 KBTBD7 gene, encodes complete protein. DQ890838 - Synthetic construct clone IMAGE:100003468; FLH166358.01X; RZPDo839F1186D kelch repeat and BTB (POZ) domain containing 7 (KBTBD7) gene, encodes complete protein. DQ893994 - Synthetic construct hom*o sapiens clone IMAGE:100008454; FLH166354.01L; RZPDo839F1185D kelch repeat and BTB (POZ) domain containing 7 (KBTBD7) gene, encodes complete protein. AB464601 - Synthetic construct DNA, clone: pF1KB9621, hom*o sapiens KBTBD7 gene for kelch repeat and BTB (POZ) domain containing 7, without stop codon, in Flexi system. AM393035 - Synthetic construct hom*o sapiens clone IMAGE:100001695 for hypothetical protein (KBTBD7 gene). AM393575 - Synthetic construct hom*o sapiens clone IMAGE:100001693 for hypothetical protein (KBTBD7 gene). CU692470 - Synthetic construct hom*o sapiens gateway clone IMAGE:100020011 5' read KBTBD7 mRNA. JD547258 - Sequence 528282 from Patent EP1572962. JD120076 - Sequence 101100 from Patent EP1572962. JD156252 - Sequence 137276 from Patent EP1572962. JD427033 - Sequence 408057 from Patent EP1572962. JD336355 - Sequence 317379 from Patent EP1572962. JD336354 - Sequence 317378 from Patent EP1572962. JD492560 - Sequence 473584 from Patent EP1572962. JD201902 - Sequence 182926 from Patent EP1572962. JD407105 - Sequence 388129 from Patent EP1572962. JD173471 - Sequence 154495 from Patent EP1572962. JD478356 - Sequence 459380 from Patent EP1572962. JD203591 - Sequence 184615 from Patent EP1572962. JD217532 - Sequence 198556 from Patent EP1572962. JD487780 - Sequence 468804 from Patent EP1572962. |
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO) Protein Q8WVZ9 (Reactome details) participates in the following event(s): R-HSA-5658424 KBTBD7:CUL3:RBX1 ubiquitinates NF1 |
Alternate Gene Symbols: B5TZ86, KBTB7_HUMAN, NM_032138, NP_115514, Q5T6Y7, Q8NB99, Q8WVZ9, Q9H0I6 UCSC ID: uc001uxw.1 RefSeq Accession: NM_032138 Protein: Q8WVZ9 (aka KBTB7_HUMAN or KBT7_HUMAN) CCDS: CCDS9377.1 |
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